Chapter 209: Smoking Cessation
Over 480,000 individuals die prematurely each year in the United States from cigarette use: one out of every five deaths nationwide. Approximately 40% of smokers will die prematurely unless they are able to quit; risks of major diseases caused by cigarette smoking are listed in Table 209-1.
| AGE | 35–44 | 45–64 | 65–74 | ≥75 |
|---|---|---|---|---|
| Males | ||||
| Lung cancer | 14.33 | 19.03 | 28.29 | 22.51 |
| Coronary heart disease | 3.88 | 2.99 | 2.76 | 1.98 |
| Cerebrovascular disease | 2.17 | 1.48 | 1.23 | 1.12 |
| Other vascular diseases | 7.25 | 4.93 | ||
| Chronic obstructive pulmonary disease (COPD) | 29.69 | 23.01 | ||
| All causes | 2.55 | 2.97 | 3.02 | 2.40 |
| Females | ||||
| Lung cancer | 13.30 | 18.95 | 23.65 | 23.08 |
| Other tobacco-related cancers | 1.28 | 2.08 | 2.06 | 1.93 |
| Coronary heart disease | 4.98 | 3.25 | 3.29 | 2.25 |
| Cerebrovascular disease | 2.27 | 1.70 | 1.24 | 1.10 |
| Other vascular diseases | 6.81 | 5.77 | ||
| COPD | 38.89 | 20.96 | ||
| All causes | 1.79 | 2.63 | 2.87 | 2.47 |
| Relative risks for selected other cancers | ||||
| Other cancers | Male | Female | ||
| Larynx | 14.6 | 13 | ||
| Lip, oral cavity, pharynx | 10.9 | 5.1 | ||
| Esophagus | 6.8 | 7.8 | ||
| Bladder | 3.3 | 2.2 | ||
| Kidney | 2.7 | 1.3 | ||
| Pancreas | 2.3 | 2.3 | ||
| Stomach | 2 | 1.4 | ||
| Liver | 1.7 | 1.7 | ||
| Colorectal | 1.2 | 1.2 | ||
| Cervix | 1.6 | |||
| Acute myeloid leukemia | 1.4 | 1.4 | ||
There's more to see -- the rest of this topic is available only to subscribers.
Citation
Kasper, Dennis L., et al., editors. "Chapter 209: Smoking Cessation." Harrison's Manual of Medicine, 20th ed., McGraw Hill Inc., 2020. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623132/0/Chapter_209:_Smoking_Cessation.
Chapter 209: Smoking Cessation. In: Kasper DLD, Fauci ASA, Hauser SLS, et al, eds. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623132/0/Chapter_209:_Smoking_Cessation. Accessed October 30, 2025.
Chapter 209: Smoking Cessation. (2020). In Kasper, D. L., Fauci, A. S., Hauser, S. L., Longo, D. L., Jameson, J. L., & Loscalzo, J. (Eds.), Harrison's Manual of Medicine (20th ed.). McGraw Hill Inc.. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623132/0/Chapter_209:_Smoking_Cessation
Chapter 209: Smoking Cessation [Internet]. In: Kasper DLD, Fauci ASA, Hauser SLS, Longo DLD, Jameson JLJ, Loscalzo JJ, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. [cited 2025 October 30]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623132/0/Chapter_209:_Smoking_Cessation.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Chapter 209: Smoking Cessation
ID - 623132
ED - Jameson,J Larry,
ED - Loscalzo,Joseph,
ED - Kasper,Dennis L,
ED - Fauci,Anthony S,
ED - Hauser,Stephen L,
ED - Longo,Dan L,
BT - Harrison's Manual of Medicine
UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623132/0/Chapter_209:_Smoking_Cessation
PB - McGraw Hill Inc.
ET - 20
DB - Harrison's Manual of Medicine
DP - Unbound Medicine
ER -

Harrison's Manual of Medicine

