Title Page

Harrison’s Manual of Medicine, 19th Edition
Copyright © 2017 by McGraw Hill Inc. All rights reserved.
Editors
Contributors
Preface
Acknowledgments
Notices and Disclaimers
Unbound™ mobile platform © 2000-2017 Unbound Medicine, Inc. All rights reserved.

Editors

Dennis L. Kasper, MD, MA(HON)
William Ellery Channing Professor of Medicine,
Professor of Microbiology and Immunobiology,
Department of Microbiology and Immunobiology,
Harvard Medical School; Division of Infectious Diseases,
Brigham and Women’s Hospital,
Boston, Massachusetts

Anthony S. Fauci, MD, ScD(HON)
Chief, Laboratory of Immunoregulation;
Director, National Institute of Allergy and Infectious Diseases,
National Institutes of Health,
Bethesda, Maryland

Stephen L. Hauser, MD
Robert A. Fishman Distinguished Professor and Chairman,
Department of Neurology,
University of California, San Francisco,
San Francisco, California

Dan L. Longo, MD
Professor of Medicine, Harvard Medical School;
Senior Physician, Brigham and Women’s Hospital;
Deputy Editor, New England Journal of Medicine
Boston, Massachusetts

J. Larry Jameson, MD, PhD
Robert G. Dunlop Professor of Medicine;
Dean, Perelman School of Medicine at the University of Pennsylvania;
Executive Vice President, University of Pennsylvania for the Health System,
Philadelphia, Pennsylvania

Joseph Loscalzo, MD, PhD
Hersey Professor of the Theory and Practice of Medicine,
Harvard Medical School; Chairman, Department of Medicine, and Physician-in-Chief,
Brigham and Women’s Hospital,
Boston, Massachusetts

Contributors

ASSOCIATE EDITORS

S. ANDREW JOSEPHSON, MD
Professor;
Senior Executive Vice Chairman, Department of Neurology,
University of California, San Francisco,
San Francisco, California

CAROL A. LANGFORD, MD, MHS
Harold C. Schott Endowed Chair;
Director, Center for Vasculitis Care and Research,
Department of Rheumatic and Immunologic Diseases,
Cleveland Clinic,
Cleveland, Ohio

LEONARD S. LILLY, MD
Professor of Medicine, Harvard Medical School;
Chief, Brigham and Women’s/Faulkner Cardiology,
Brigham and Women’s Hospital,
Boston, Massachusetts

DAVID B. MOUNT, MD
Associate Physician, Brigham and Women’s Hospital;
Assistant Professor of Medicine, Harvard Medical School;
Renal Division, Brigham and Women’s Hospital,
Boston, Massachusetts

EDWIN K. SILVERMAN, MD, PhD
Professor of Medicine;
Chief, Channing Division of Network Medicine,
Harvard Medical School,
Boston, Massachusetts

NEERAJ K. SURANA, MD, PhD
Instructor in Pediatrics, Harvard Medical School;
Assistant in Medicine, Boston Children’s Hospital,
Boston, Massachusetts

Numbers indicate the chapters written or co-written by the contributor.

ANTHONY S. FAUCI, MD
26, 42, 43, 47, 59, 60, 105, 150-167

GREGORY K. FOLKERS, MPH
105, 153, 159

STEPHEN L. HAUSER, MD
3, 5, 16-22, 48-56, 77, 180-200, 204

J. LARRY JAMESON, MD, PhD
2, 6, 7, 23, 24, 29, 30, 118, 168-179, 198, 201, 205

S. ANDREW JOSEPHSON, MD
5, 16-22, 48-56, 77, 180-197, 199, 200, 204

DENNIS L. KASPER, MD
12, 27, 28, 57, 58, 78-104, 106-109, 132, 144

SHYAMASUNDARAN KOTTILIL, MD
153

CAROL A. LANGFORD, MD

26, 42, 43, 47, 59, 60, 105, 150-167

LEONARD S. LILLY, MD
10, 11, 13, 31, 32, 34, 110-117, 119-127

DAN L. LONGO, MD
8, 9, 25, 37-41, 44, 45, 61-76, 147-149, 203

JOSEPH LOSCALZO, MD, PhD
4, 10, 11, 13-15, 31-36, 46, 110-117, 119-143, 145, 146, 202

DAVID B. MOUNT, MD
36, 46, 138-143, 145, 146

EDWIN K. SILVERMAN, MD, PhD
4, 14, 15, 33, 35, 128-137

NEERAJ K. SURANA, MD, PhD
12, 27, 28, 57, 58, 78-104, 106-109, 132, 144

Preface

Harrison’s Principles of Internal Medicine (HPIM), the premier medical textbook for students and clinicians, provides a detailed body of information important to an understanding of the biological and clinical aspects of quality patient care. Harrison’s Manual of Medicine aims to fulfill a different need: As a concise, fact-rich resource for bedside care, the Manual presents clinical information drawn from the 19th edition of HPIM, covering the key features of the diagnosis, clinical manifestations, and treatment of the major diseases that are likely to be encountered on a medical service.

First published in 1988, the Manual has become ever more useful with the rapid expansion of medical knowledge and the increasing time constraints associated with heavy patient-care responsibilities in modern health care settings. The Manual’s popularity and value reflect its abbreviated format, which has proven extremely useful for initial diagnosis and management in time-restricted clinical settings. In particular, the book’s full-color format allows readers to locate and use information quickly. In addition, numerous tables and graphics facilitate decisions at the point of care.

The Manual has been written for easy and seamless reference to the full text of the 19th edition of HPIM, and the Editors recommend that the full textbook be consulted as soon as time allows. Although not a substitute for in-depth analysis of clinical problems, the Manual serves as a ready source of informative summaries that will be useful "on the spot" and that will prepare the reader for more in-depth analysis through more extensive reading at a later time. Like previous editions, this latest edition of the Manual is intended to keep up with the continual evolution of internal medicine practices. To this end, every chapter from the prior edition has been closely reviewed and updated, with substantial revisions and new chapters provided where appropriate. The 19th edition of the Manual is available in print and in portable format for the smartphone and tablet.

Acknowledgments

The Editors and McGraw-Hill wish to thank their editorial staff, whose assistance and patience made this edition come out in a timely manner:

From the Editors’ offices: Patricia Duffey; Gregory K. Folkers; Andrew Josephson, MD; H. Clifford Lane, MD; Carol A. Langford, MD; Julie B. McCoy; Anita Ortiz; Elizabeth Robbins, MD; Marie E. Scurti; and Stephanie Tribuna.

From McGraw-Hill: James F. Shanahan, Kim J. Davis, and Catherine H. Saggese.

The Editors also wish to acknowledge contributors to past editions of this Manual, whose work formed the basis for many of the chapters herein: Tamar F. Barlam, MD; Gerhard P. Baumann, MD; Eugene Braunwald, MD; Punit Chadha, MD; Joseph B. Martin, MD, PhD; Michael Sneller, MD; Kenneth Tyler, MD; Sophia Vinogradov, MD; and Jean Wilson, MD.

Notices and Disclaimers

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