SINOATRIAL NODE DYSFUNCTION is a topic covered in the
Harrison's Manual of Medicine.
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Etiologies are either intrinsic (degenerative, ischemic, inflammatory, infiltrative [e.g., amyloid], or rare mutations in sodium channel or pacemaker current genes) or extrinsic (e.g., drugs [beta blockers, Ca++ channel blockers, digoxin], autonomic dysfunction, hypothyroidism).
Symptoms are due to bradycardia (fatigue, weakness, lightheadedness, syncope) and/or episodes of associated tachycardia (e.g., rapid palpitations, angina) in pts with sick sinus syndrome (SSS).
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Citation
Loscalzo, Joseph, et al., editors. "SINOATRIAL NODE DYSFUNCTION." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623736/all/SINOATRIAL_NODE_DYSFUNCTION.
SINOATRIAL NODE DYSFUNCTION. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623736/all/SINOATRIAL_NODE_DYSFUNCTION. Accessed December 15, 2019.
SINOATRIAL NODE DYSFUNCTION. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623736/all/SINOATRIAL_NODE_DYSFUNCTION
SINOATRIAL NODE DYSFUNCTION [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 December 15]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623736/all/SINOATRIAL_NODE_DYSFUNCTION.
TY - ELEC
T1 - SINOATRIAL NODE DYSFUNCTION
ID - 623736
ED - Loscalzo,Joseph,
ED - Jameson,J Larry,
ED - Longo,Dan L,
ED - Hauser,Stephen L,
ED - Fauci,Anthony S,
ED - Kasper,Dennis L,
BT - Harrison's Manual of Medicine
UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623736/all/SINOATRIAL_NODE_DYSFUNCTION
PB - McGraw Hill Inc.
ET - 19
DB - Harrison's Manual of Medicine
DP - Unbound Medicine
ER -
Harrison's Manual of Medicine
