Chapter 161: Systemic Lupus Erythematosus

Chapter 161: Systemic Lupus Erythematosus is a topic covered in the Harrison's Manual of Medicine.

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Harrison’s Manual of Medicine

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DEFINITION AND PATHOGENESIS

Disease of unknown etiology in which tissues and cells undergo damage mediated by tissue-binding autoantibodies and immune complexes. Genetic, environmental, and sex hormonal factors are likely of pathogenic importance. T- and B-cell hyperactivity, production of autoantibodies with specificity for nuclear antigenic determinants, and abnormalities of T-cell function occur.

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