CHRONIC MYELOID LEUKEMIA is a topic covered in the Harrison's Manual of Medicine.

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Harrison’s Manual of Medicine

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CML is a clonal malignancy usually characterized by splenomegaly and production of increased numbers of granulocytes; course is initially indolent but eventuates in leukemic phase (blast crisis) that has a poorer prognosis than de novo AML; rate of progression to blast crisis is variable; overall survival averages 4 years from diagnosis.

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