WHIPPLE’S DISEASE

WHIPPLE’S DISEASE is a topic covered in the Harrison's Manual of Medicine.

To view the entire topic, please or .

Harrison’s Manual of Medicine 20th edition provides 600+ internal medicine topics in a rapid-access format. Download Harrison’s App to iPhone, iPad, and Android smartphone and tablet. Explore these free sample topics:

-- The first section of this topic is shown below --

MICROBIOLOGY AND EPIDEMIOLOGY

Whipple’s disease is a chronic multiorgan infection caused by Tropheryma whipplei, a weakly staining gram-positive bacillus. Humans are the only known host. Seroprevalence studies indicate that ∼50% of people in Western Europe and ∼75% of those in rural Senegal have been exposed to T. whipplei, and the disease prevalence is estimated at 1–3 cases per 1 million population. The route of transmission is unclear but probably involves fecal–oral spread and possibly involves droplet and/or airborne transmission.

-- To view the remaining sections of this topic, please or --

MICROBIOLOGY AND EPIDEMIOLOGY

Whipple’s disease is a chronic multiorgan infection caused by Tropheryma whipplei, a weakly staining gram-positive bacillus. Humans are the only known host. Seroprevalence studies indicate that ∼50% of people in Western Europe and ∼75% of those in rural Senegal have been exposed to T. whipplei, and the disease prevalence is estimated at 1–3 cases per 1 million population. The route of transmission is unclear but probably involves fecal–oral spread and possibly involves droplet and/or airborne transmission.

There's more to see -- the rest of this entry is available only to subscribers.