CHOLEDOCHOLITHIASIS/CHOLANGITIS
ETIOLOGY
In pts with cholelithiasis, passage of gallstones into CBD occurs in 10–15%; increases with age. At cholecystectomy, undetected stones are left behind in 1–5% of pts.
SYMPTOMS AND SIGNS
Choledocholithiasis may present as an incidental finding, biliary colic, obstructive jaundice, cholangitis, or pancreatitis. Cholangitis usually presents as fever, RUQ pain, and jaundice (Charcot’s triad).
LABORATORY
Elevations in serum bilirubin, alkaline phosphatase, and aminotransferases. Leukocytosis usually accompanies cholangitis; blood cultures are frequently positive. Biochemical evidence of pancreatic inflammation is seen in >30% of cases.
IMAGING
Diagnosis usually made by cholangiography either preoperatively by endoscopic retrograde cholangiopancreatography (ERCP), magnetic resonance cholangiopancreatography (MRCP), or intraoperatively at the time of cholecystectomy. Ultrasonography may reveal dilated bile ducts but has poor visualization of the distal CBD (Table 153-1).
DIFFERENTIAL DIAGNOSIS
Acute cholecystitis, renal colic, perforated viscus, pancreatitis.
COMPLICATIONS
Cholangitis, obstructive jaundice, gallstone-induced pancreatitis, and secondary biliary cirrhosis.
Treatment: Choledocholithiasis/Cholangitis
Treatment: Choledocholithiasis/Cholangitis
Laparoscopic cholecystectomy and ERCP have decreased the need for choledocholithotomy and T-tube drainage of the bile ducts. When CBD stones are suspected prior to laparoscopic cholecystectomy, preoperative ERCP with endoscopic papillotomy and stone extraction is the preferred approach. CBD stones should be suspected in gallstone pts with (1) history of jaundice or pancreatitis, (2) abnormal LFT, and (3) ultrasound evidence of a dilated CBD or stones in the duct. Cholangitis treated like acute cholecystitis; no oral intake, hydration, analgesia, and antibiotics are the mainstays; stones should be removed surgically or endoscopically.
Outline
CHOLEDOCHOLITHIASIS/CHOLANGITISis the Harrison's Manual of Medicine Word of the day!
Citation
Kasper, Dennis L., et al., editors. "CHOLEDOCHOLITHIASIS/CHOLANGITIS." Harrison's Manual of Medicine, 20th ed., McGraw Hill Inc., 2020. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623672/all/CHOLEDOCHOLITHIASIS_CHOLANGITIS.
CHOLEDOCHOLITHIASIS/CHOLANGITIS. In: Kasper DLD, Fauci ASA, Hauser SLS, et al, eds. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623672/all/CHOLEDOCHOLITHIASIS_CHOLANGITIS. Accessed August 23, 2025.
CHOLEDOCHOLITHIASIS/CHOLANGITIS. (2020). In Kasper, D. L., Fauci, A. S., Hauser, S. L., Longo, D. L., Jameson, J. L., & Loscalzo, J. (Eds.), Harrison's Manual of Medicine (20th ed.). McGraw Hill Inc.. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623672/all/CHOLEDOCHOLITHIASIS_CHOLANGITIS
CHOLEDOCHOLITHIASIS/CHOLANGITIS [Internet]. In: Kasper DLD, Fauci ASA, Hauser SLS, Longo DLD, Jameson JLJ, Loscalzo JJ, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. [cited 2025 August 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623672/all/CHOLEDOCHOLITHIASIS_CHOLANGITIS.
* Article titles in AMA citation format should be in sentence-case
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T1 - CHOLEDOCHOLITHIASIS/CHOLANGITIS
ID - 623672
ED - Jameson,J Larry,
ED - Loscalzo,Joseph,
ED - Kasper,Dennis L,
ED - Fauci,Anthony S,
ED - Hauser,Stephen L,
ED - Longo,Dan L,
BT - Harrison's Manual of Medicine
UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623672/all/CHOLEDOCHOLITHIASIS_CHOLANGITIS
PB - McGraw Hill Inc.
ET - 20
DB - Harrison's Manual of Medicine
DP - Unbound Medicine
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