Harrison's Manual of Medicine
SJÖGREN’S SYNDROME
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DEFINITION
An immunologic disorder characterized by progressive lymphocytic destruction of exocrine glands most frequently resulting in symptomatic eye and mouth dryness; can be associated with extraglandular manifestations; predominantly affects middle-age females; may be primary or secondary when it occurs in association with other autoimmune diseases. Lymphoma can occur in 6% with glandular MALT being most common.
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DEFINITION
An immunologic disorder characterized by progressive lymphocytic destruction of exocrine glands most frequently resulting in symptomatic eye and mouth dryness; can be associated with extraglandular manifestations; predominantly affects middle-age females; may be primary or secondary when it occurs in association with other autoimmune diseases. Lymphoma can occur in 6% with glandular MALT being most common.
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