PERTUSSIS is a topic covered in the Harrison's Manual of Medicine.

To view the entire topic, please or purchase a subscription.

Harrison’s Manual of Medicine 19th edition provides 600+ internal medicine topics in a rapid-access format. Download Harrison’s App to iPhone, iPad, and Android smartphone and tablet. Explore these free sample topics:

Harrison’s Manual of Medicine - App + Web

-- The first section of this topic is shown below --

MICROBIOLOGY AND PATHOGENESIS

Bordetella pertussis, the etiologic agent of pertussis, is a fastidious gram-negative pleomorphic aerobic bacillus that attaches to ciliated epithelial cells of the nasopharynx, multiplies locally, and produces a wide array of toxins and biologically active products.

  • B. parapertussis causes a similar, though typically milder, illness. B. holmesii causes up to 20% of pertussis-like syndromes.
  • The most important toxin in B. pertussis is pertussis toxin, which has ADP ribosylating activity. The absence of this toxin in B. parapertussis may explain the milder illness.

-- To view the remaining sections of this topic, please or purchase a subscription --

Citation

* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - PERTUSSIS ID - 623657 ED - Fauci,Anthony S, ED - Hauser,Stephen L, ED - Jameson,J Larry, ED - Kasper,Dennis L, ED - Longo,Dan L, ED - Loscalzo,Joseph, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623657/all/PERTUSSIS PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -