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NONINFLAMMATORY DIARRHEA is a topic covered in the Harrison's Manual of Medicine.

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If there is evidence of a common-source outbreak, questions concerning the ingestion of specific foods and the timing of diarrhea after a meal can provide clues to the bacterial cause of the illness.

  • Staphylococcus aureus: Enterotoxin is elaborated in food left at room temperature (e.g., at picnics).
    • The incubation period is 1–6 h. Disease lasts <12 h and consists of diarrhea, nausea, vomiting, and abdominal cramping, usually without fever.
    • Most cases are due to contamination from infected human carriers.
  • Bacillus cereus: Either an emetic or a diarrheal form of food poisoning can occur.
    • The emetic form presents like S. aureus food poisoning, is due to a staphylococcal type of enterotoxin, has an incubation period of 1–6 h, and is associated with contaminated fried rice.
    • The diarrheal form has an incubation period of 8–16 h, is caused by an enterotoxin resembling Escherichia coli heat-labile toxin (LT), and presents as diarrhea and abdominal cramps without vomiting.
  • Clostridium perfringens: Ingestion of heat-resistant spores in undercooked meat, poultry, or legumes leads to toxin production in the intestinal tract. The incubation period is 8–14 h, after which pts develop ≤24 h of diarrhea and abdominal cramps, without vomiting or fever.

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Loscalzo, Joseph, et al., editors. "NONINFLAMMATORY DIARRHEA." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623641/all/NONINFLAMMATORY_DIARRHEA.
NONINFLAMMATORY DIARRHEA. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623641/all/NONINFLAMMATORY_DIARRHEA. Accessed April 23, 2019.
NONINFLAMMATORY DIARRHEA. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623641/all/NONINFLAMMATORY_DIARRHEA
NONINFLAMMATORY DIARRHEA [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623641/all/NONINFLAMMATORY_DIARRHEA.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - NONINFLAMMATORY DIARRHEA ID - 623641 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623641/all/NONINFLAMMATORY_DIARRHEA PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -