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AGGRESSIVE LYMPHOMAS is a topic covered in the Harrison's Manual of Medicine.

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A large number of pathologic entities share an aggressive natural history; median survival untreated is 6 months, and nearly all untreated pts are dead within 1 year. Pts may present with asymptomatic adenopathy or symptoms referable to involvement of practically any nodal or extranodal site: Mediastinal involvement may produce superior vena cava syndrome or pericardial tamponade; retroperitoneal nodes may obstruct ureters; abdominal masses may produce pain, ascites, or GI obstruction or perforation; CNS involvement may produce confusion, cranial nerve signs, headache, seizures, and/or spinal cord compression; bone involvement may produce pain or pathologic fracture. About 45% of pts have B symptoms.

Diffuse large B-cell lymphoma is the most common histologic diagnosis among the aggressive lymphomas, accounting for 35–45% of all lymphomas. Aggressive lymphomas together account for ~60% of all lymphoid tumors. About 85% of aggressive lymphomas are of mature B-cell origin; 15% are derived from peripheral (postthymic) T cells.

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Loscalzo, Joseph, et al., editors. "AGGRESSIVE LYMPHOMAS." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623598/all/AGGRESSIVE_LYMPHOMAS.
AGGRESSIVE LYMPHOMAS. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623598/all/AGGRESSIVE_LYMPHOMAS. Accessed April 23, 2019.
AGGRESSIVE LYMPHOMAS. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623598/all/AGGRESSIVE_LYMPHOMAS
AGGRESSIVE LYMPHOMAS [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623598/all/AGGRESSIVE_LYMPHOMAS.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - AGGRESSIVE LYMPHOMAS ID - 623598 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623598/all/AGGRESSIVE_LYMPHOMAS PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -