MYELOPROLIFERATIVE SYNDROMES

MYELOPROLIFERATIVE SYNDROMES is a topic covered in the Harrison's Manual of Medicine.

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The three major myeloproliferative syndromes are polycythemia vera, idiopathic myelofibrosis, and essential thrombocytosis. All are clonal disorders of hematopoietic stem cells and all are associated with a mutation in the JAK2 kinase (V617F) that results in activation of the kinase. The mutation is seen in 90% of pts with polycythemia vera and ~45% of pts with idiopathic myelofibrosis and essential thrombocytosis.

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TY - ELEC T1 - MYELOPROLIFERATIVE SYNDROMES ID - 623595 Y1 - 2017 PB - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623595/all/MYELOPROLIFERATIVE_SYNDROMES ER -