HYPERTHERMIA
- Etiology: Exogenous heat exposure (e.g., heat stroke) and endogenous heat production (e.g., drug-induced hyperthermia, malignant hyperthermia) are two mechanisms by which hyperthermia can result in dangerously high internal temperatures.
- Heat stroke: Thermoregulatory failure in association with a warm environment; can be categorized as exertional (e.g., due to exercise in high heat or humidity) or classic (typically occurring in pts with chronic diseases that predispose to heat-related illnesses)
- Clinical features: High core temperature in association with an appropriate history (heat exposure, certain drug treatments) and dry skin, hallucinations, delirium, pupil dilation, muscle rigidity, and/or elevated levels of CPK
- Diagnosis: It can be difficult to distinguish fever from hyperthermia. The clinical history is often most useful (e.g., a history of heat exposure or of treatment with drugs that interfere with thermoregulation).
- Hyperthermic pts have hot, dry skin; antipyretic agents do not lower the body temperature.
- Febrile pts can have cold skin (as a result of vasoconstriction) or hot, moist skin; antipyretics usually result in some lowering of the body temperature.
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Citation
Kasper, Dennis L., et al., editors. "HYPERTHERMIA." Harrison's Manual of Medicine, 20th ed., McGraw Hill Inc., 2020. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623542/all/HYPERTHERMIA.
HYPERTHERMIA. In: Kasper DLD, Fauci ASA, Hauser SLS, et al, eds. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623542/all/HYPERTHERMIA. Accessed December 2, 2024.
HYPERTHERMIA. (2020). In Kasper, D. L., Fauci, A. S., Hauser, S. L., Longo, D. L., Jameson, J. L., & Loscalzo, J. (Eds.), Harrison's Manual of Medicine (20th ed.). McGraw Hill Inc.. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623542/all/HYPERTHERMIA
HYPERTHERMIA [Internet]. In: Kasper DLD, Fauci ASA, Hauser SLS, Longo DLD, Jameson JLJ, Loscalzo JJ, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. [cited 2024 December 02]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623542/all/HYPERTHERMIA.
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