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FEVER OF UNKNOWN ORIGIN is a topic covered in the Harrison's Manual of Medicine.

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  • Etiology: FUO is more commonly caused by an atypical presentation of a common disease than by a very rare disease. The most common causes of FUO can be categorized as infections, neoplasms, or noninfectious inflammatory diseases (NIIDs; e.g., “collagen or rheumatic diseases,” vasculitis syndromes, and granulomatous disorders). The frequency of each category differs between Western countries and countries in other parts of the world: infections, neoplasms, and NIIDs account for 22%, 11%, and 23% of Western cases, respectively, and for 43%, 16%, and 23% of cases in other geographic regions.
    • Atypical presentations of endocarditis, diverticulitis, vertebral osteomyelitis, and extrapulmonary tuberculosis represent the more common infectious-disease diagnoses.
    • The most common NIIDs that result in FUO are large-vessel vasculitis, polymyalgia rheumatica, sarcoidosis, familial Mediterranean fever, and adult-onset Still’s disease.
    • Among the neoplasms, malignant lymphoma is by far the most common cause of FUO. Fever occasionally precedes lymphadenopathy detectable by physical examination.

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Loscalzo, Joseph, et al., editors. "FEVER of UNKNOWN ORIGIN." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623541/all/FEVER_OF_UNKNOWN_ORIGIN.
FEVER OF UNKNOWN ORIGIN. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623541/all/FEVER_OF_UNKNOWN_ORIGIN. Accessed April 21, 2019.
FEVER OF UNKNOWN ORIGIN. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623541/all/FEVER_OF_UNKNOWN_ORIGIN
FEVER of UNKNOWN ORIGIN [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 21]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623541/all/FEVER_OF_UNKNOWN_ORIGIN.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - FEVER OF UNKNOWN ORIGIN ID - 623541 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623541/all/FEVER_OF_UNKNOWN_ORIGIN PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -