HYPERGLYCEMIC HYPEROSMOLAR STATE

HYPERGLYCEMIC HYPEROSMOLAR STATE is a topic covered in the Harrison's Manual of Medicine.

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ETIOLOGY

Relative insulin deficiency and inadequate fluid intake are the underlying causes of HHS. Hyperglycemia induces an osmotic diuresis that leads to profound intravascular volume depletion. HHS is often precipitated by a serious, concurrent illness such as myocardial infarction or sepsis and is compounded by conditions that impede access to water.

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ETIOLOGY

Relative insulin deficiency and inadequate fluid intake are the underlying causes of HHS. Hyperglycemia induces an osmotic diuresis that leads to profound intravascular volume depletion. HHS is often precipitated by a serious, concurrent illness such as myocardial infarction or sepsis and is compounded by conditions that impede access to water.

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