ENDOCRINE AND METABOLIC MYOPATHIES

ENDOCRINE AND METABOLIC MYOPATHIES is a topic covered in the Harrison's Manual of Medicine.

To view the entire topic, please or purchase a subscription.

Harrison’s Manual of Medicine 19th edition provides 600+ internal medicine topics in a rapid-access format. Download Harrison’s App to iPhone, iPad, and Android smartphone and tablet. Explore these free sample topics:

Harrison’s Manual of Medicine - App + Web

-- The first section of this topic is shown below --

Abnormalities of thyroid function can cause a wide array of muscle disorders. Hypothyroidism is associated with muscle cramps, pain, and stiffness, and proximal muscle weakness occurs in one-third of pts; the relaxation phase of muscle stretch reflexes is prolonged, and serum CK is often elevated (up to 10 times normal).

Hyperthyroidism can produce proximal muscle weakness and atrophy; bulbar, respiratory, and even esophageal muscles are occasionally involved, causing dysphagia, dysphonia, and aspiration. Other neuromuscular disorders associated with hyperthyroidism include hypoKPP, myasthenia gravis, and a progressive ocular myopathy associated with proptosis (Graves’ ophthalmopathy).

Parathyroid, adrenal, and pituitary disorders, as well as diabetes mellitus, can also produce myopathy. Deficiencies of vitamins D and E are additional causes of muscle weakness.

-- To view the remaining sections of this topic, please or purchase a subscription --