PERIODIC PARALYSES
Muscle membrane excitability is affected in a group of disorders referred to as channelopathies. Onset is usually in childhood or adolescence. Episodes typically occur after rest or sleep, often following earlier exercise. May be due to genetic disorders of calcium (hypokalemic periodic paralysis [hypoKPP]), sodium (hyperkalemic periodic paralysis), chloride, or potassium channels.
- Attacks of hypoKPP are treated with potassium chloride (usually oral). Prophylaxis with acetazolamide (125–1000 mg/d in divided doses) or dichlorphenamide is usually effective in hypoKPP type 1.
- Attacks of thyrotoxic periodic paralysis (usually in Asian men) resemble those of hypoKPP; attacks abate with treatment of the underlying thyroid condition.
There's more to see -- the rest of this topic is available only to subscribers.
Citation
Kasper, Dennis L., et al., editors. "PERIODIC PARALYSES." Harrison's Manual of Medicine, 20th ed., McGraw Hill Inc., 2020. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623491/all/PERIODIC_PARALYSES.
PERIODIC PARALYSES. In: Kasper DLD, Fauci ASA, Hauser SLS, et al, eds. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623491/all/PERIODIC_PARALYSES. Accessed December 9, 2024.
PERIODIC PARALYSES. (2020). In Kasper, D. L., Fauci, A. S., Hauser, S. L., Longo, D. L., Jameson, J. L., & Loscalzo, J. (Eds.), Harrison's Manual of Medicine (20th ed.). McGraw Hill Inc.. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623491/all/PERIODIC_PARALYSES
PERIODIC PARALYSES [Internet]. In: Kasper DLD, Fauci ASA, Hauser SLS, Longo DLD, Jameson JLJ, Loscalzo JJ, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. [cited 2024 December 09]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623491/all/PERIODIC_PARALYSES.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - PERIODIC PARALYSES
ID - 623491
ED - Jameson,J Larry,
ED - Loscalzo,Joseph,
ED - Kasper,Dennis L,
ED - Fauci,Anthony S,
ED - Hauser,Stephen L,
ED - Longo,Dan L,
BT - Harrison's Manual of Medicine
UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623491/all/PERIODIC_PARALYSES
PB - McGraw Hill Inc.
ET - 20
DB - Harrison's Manual of Medicine
DP - Unbound Medicine
ER -