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PERIODIC PARALYSES

PERIODIC PARALYSES is a topic covered in the Harrison's Manual of Medicine.

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Muscle membrane excitability is affected in a group of disorders referred to as channelopathies. Onset is usually in childhood or adolescence. Episodes typically occur after rest or sleep, often following earlier exercise. May be due to genetic disorders of calcium (hypokalemic periodic paralysis [hypoKPP]), sodium (hyperkalemic periodic paralysis), chloride, or potassium channels.

  • Attacks of hypoKPP are treated with potassium chloride (usually oral). Prophylaxis with acetazolamide (125–1000 mg/d in divided doses) is usually effective in hypoKPP type 1.
  • Attacks of thyrotoxic periodic paralysis (usually in Asian men) resemble those of hypoKPP; attacks abate with treatment of the underlying thyroid condition.

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Citation

Loscalzo, Joseph, et al., editors. "PERIODIC PARALYSES." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623491/all/PERIODIC_PARALYSES.
PERIODIC PARALYSES. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623491/all/PERIODIC_PARALYSES. Accessed April 23, 2019.
PERIODIC PARALYSES. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623491/all/PERIODIC_PARALYSES
PERIODIC PARALYSES [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623491/all/PERIODIC_PARALYSES.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - PERIODIC PARALYSES ID - 623491 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623491/all/PERIODIC_PARALYSES PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -