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DISORDERS OF MUSCLE ENERGY METABOLISM is a topic covered in the Harrison's Manual of Medicine.

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The two principal sources of energy for skeletal muscle are fatty acids and glucose. Abnormalities in either glucose or lipid utilization can be associated with distinct clinical presentations that can range from an acute, painful syndrome with rhabdomyolysis and myoglobinuria to a chronic, progressive muscle weakness simulating muscular dystrophy. Diagnosis usually requires biochemical-enzymatic studies of biopsied muscle.

Progressive muscle weakness usually beginning in the third or fourth decade can be due to the adult form of acid maltase deficiency (Pompe’s disease). Respiratory failure is often the initial manifestation; treatment with enzyme replacement may be of benefit. Progressive weakness beginning after puberty occurs with debranching enzyme deficiency. Glycolytic defects, including myophosphorylase deficiency (McArdle’s disease) or phosphofructokinase deficiency, present as exercise intolerance with myalgias. Disorders of fatty acid metabolism present with a similar picture. In adults, the most common cause is carnitine palmitoyltransferase deficiency. Exercise-induced cramps and myoglobinuria are common; strength is normal between attacks. Dietary approaches (frequent meals and a low-fat high-carbohydrate diet, or a diet rich in medium-chain triglycerides) are of uncertain value.

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Loscalzo, Joseph, et al., editors. "DISORDERS of MUSCLE ENERGY METABOLISM." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623489/all/DISORDERS_OF_MUSCLE_ENERGY_METABOLISM.
DISORDERS OF MUSCLE ENERGY METABOLISM. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623489/all/DISORDERS_OF_MUSCLE_ENERGY_METABOLISM. Accessed April 23, 2019.
DISORDERS OF MUSCLE ENERGY METABOLISM. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623489/all/DISORDERS_OF_MUSCLE_ENERGY_METABOLISM
DISORDERS of MUSCLE ENERGY METABOLISM [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623489/all/DISORDERS_OF_MUSCLE_ENERGY_METABOLISM.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - DISORDERS OF MUSCLE ENERGY METABOLISM ID - 623489 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623489/all/DISORDERS_OF_MUSCLE_ENERGY_METABOLISM PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -