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TUMORS METASTATIC TO THE NERVOUS SYSTEM

TUMORS METASTATIC TO THE NERVOUS SYSTEM is a topic covered in the Harrison's Manual of Medicine.

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Hematogenous spread most common. Skull metastases rarely invade CNS; may compress adjacent brain or cranial nerves or obstruct intracranial venous sinuses. Primary tumors that commonly metastasize to the nervous system are listed in Table 189-1. Brain metastases are well demarcated by MRI and enhance with gadolinium. Ring enhancement is nonspecific; differential diagnosis includes brain abscess, radiation necrosis, toxoplasmosis, granulomas, tuberculosis, sarcoidosis, demyelinating lesions, primary brain tumors, CNS lymphoma, stroke, hemorrhage, and trauma. Screen for occult cancer: examine skin and thyroid gland; blood carcinoembryonic antigen (CEA) and liver function tests; CT of chest, abdomen, and pelvis. In approximately 10% of pts, a systemic cancer may present with brain metastases; biopsy of primary tumor or accessible brain metastasis is needed to plan treatment. Treatment with glucocorticoids, anticonvulsants, RT, or surgery. Whole-brain RT is often given because multiple microscopic tumor deposits are likely throughout the brain; stereotaxic radiosurgery is of benefit in pts with three or fewer metastases demonstrated by MRI. If a single metastasis is found, it may be surgically excised followed by whole-brain RT. Systemic chemotherapy may produce dramatic responses in rare cases of a highly chemosensitive tumor type such as germ cell tumors or small-cell lung cancer harboring specific epidermal growth factor receptor (EGFR) mutations that sensitize them to EGFR inhibitors.

TABLE 189-1: FREQUENCY OF NERVOUS SYSTEM METASTASES BY COMMON PRIMARY TUMORS
 Brain %LM %ESCC %
Lung411715
Breast195722
Melanoma1012 4
Prostate 1 110
GIT 7 5
Renal 3 2 7
Lymphoma<11010
Sarcoma 7 1 9
Other1118
Abbreviations: ESCC, epidural spinal cord compression; GIT, gastrointestinal tract; LM, leptomeningeal metastases.

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Citation

Loscalzo, Joseph, et al., editors. "TUMORS METASTATIC to the NERVOUS SYSTEM." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623478/all/TUMORS_METASTATIC_TO_THE_NERVOUS_SYSTEM.
TUMORS METASTATIC TO THE NERVOUS SYSTEM. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623478/all/TUMORS_METASTATIC_TO_THE_NERVOUS_SYSTEM. Accessed April 23, 2019.
TUMORS METASTATIC TO THE NERVOUS SYSTEM. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623478/all/TUMORS_METASTATIC_TO_THE_NERVOUS_SYSTEM
TUMORS METASTATIC to the NERVOUS SYSTEM [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623478/all/TUMORS_METASTATIC_TO_THE_NERVOUS_SYSTEM.
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TY - ELEC T1 - TUMORS METASTATIC TO THE NERVOUS SYSTEM ID - 623478 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623478/all/TUMORS_METASTATIC_TO_THE_NERVOUS_SYSTEM PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -