HYPERNATREMIA
This is rarely associated with hypervolemia, where the association is typically iatrogenic, e.g., administration of hypertonic sodium bicarbonate. More commonly, hypernatremia is the result of a combined H2O and volume deficit, with losses of H2O in excess of Na+. Elderly individuals with reduced thirst and/or diminished access to fluids are at the highest risk of hypernatremia due to decreased free H2O intake. Common causes of renal H2O loss are osmotic diuresis secondary to hyperglycemia, postobstructive diuresis, or drugs (radiocontrast, mannitol, etc.); H2O diuresis occurs in central or nephrogenic diabetes insipidus (DI) (Chap. 172: Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone). In pts with hypernatremia due to renal loss of H2O, it is critical to quantify ongoing daily losses in addition to calculation of the baseline H2O deficit (Table 1-2).
Table 1-2: Correction of Hypernatremia |
H2O Deficit |
|
Ongoing H2O Losses |
4. Calculate free-water clearance, CeH2O: where V is urinary volume, UNa is urinary [Na+], UK is urinary [K+], and SNa is serum [Na+]. |
Insensible Losses |
5. ∼10 mL/kg per day: less if ventilated, more if febrile |
Total |
6. Add components to determine H2O deficit and ongoing H2O loss; correct the H2O deficit over 48–72 h and replace daily H2O loss. |
Abbreviation: TBW, total-body water.
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Citation
Kasper, Dennis L., et al., editors. "HYPERNATREMIA." Harrison's Manual of Medicine, 20th ed., McGraw Hill Inc., 2020. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623467/all/HYPERNATREMIA.
HYPERNATREMIA. In: Kasper DLD, Fauci ASA, Hauser SLS, et al, eds. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623467/all/HYPERNATREMIA. Accessed December 9, 2024.
HYPERNATREMIA. (2020). In Kasper, D. L., Fauci, A. S., Hauser, S. L., Longo, D. L., Jameson, J. L., & Loscalzo, J. (Eds.), Harrison's Manual of Medicine (20th ed.). McGraw Hill Inc.. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623467/all/HYPERNATREMIA
HYPERNATREMIA [Internet]. In: Kasper DLD, Fauci ASA, Hauser SLS, Longo DLD, Jameson JLJ, Loscalzo JJ, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. [cited 2024 December 09]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623467/all/HYPERNATREMIA.
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