OSTEOMALACIA

ETIOLOGY

Defective mineralization of the organic matrix of bone results in osteomalacia. The childhood form of osteomalacia is called rickets. Osteomalacia is caused by inadequate intake or malabsorption of vitamin D (chronic pancreatic insufficiency, gastrectomy, malabsorption) and disorders of vitamin D metabolism (anticonvulsant therapy, chronic renal failure, genetic disorders of vitamin D activation or action). Osteomalacia can also be caused by long-standing hypophosphatemia, which can be due to renal phosphate wasting (e.g., X-linked hypophosphatemic rickets or oncogenic osteomalacia) or excessive use of phosphate binders.

There's more to see -- the rest of this topic is available only to subscribers.