SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE (SIADH)

SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE (SIADH) is a topic covered in the Harrison's Manual of Medicine.

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Etiology

Excessive or inappropriate production of AVP predisposes to hyponatremia, reflecting water retention. The evaluation of hyponatremia is described in Chap. 1. Etiologies of SIADH include neoplasms, lung infections, CNS disorders, and drugs (Table 169-1).

TABLE 169-1: CAUSES OF SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE (SIADH)
NeoplasmsNeurologic
 Carcinomas Guillain-Barré syndrome
  Lung Multiple sclerosis
  Duodenum Delirium tremens
  Pancreas Amyotrophic lateral sclerosis
  Ovary Hydrocephalus
  Bladder, ureter Psychosis
 Other neoplasms Peripheral neuropathy
  ThymomaCongenital malformations
  Mesothelioma Agenesis corpus callosum
  Bronchial adenoma Cleft lip/palate
  Carcinoid Other midline defects
  GangliocytomaMetabolic
  Ewing’s sarcoma Acute intermittent porphyria
Head traumaPulmonary
Infections Asthma
 Pneumonia, bacterial or viral Pneumothorax
 Abscess, lung or brain Positive-pressure respiration
 Cavitation (aspergillosis)Drugs
 Tuberculosis, lung or brain Vasopressin or desmopressin
 Meningitis, bacterial or viral Chlorpropamide
 Encephalitis Oxytocin, high dose
 AIDS Vincristine
Vascular Carbamazepine

 Cerebrovascular occlusions, hemorrhage

 Nicotine

 Cavernous sinus thrombosis

 Phenothiazines

Genetic

 Cyclophosphamide

 X-linked recessive

 Tricyclic antidepressants

 (V2 receptor gene)

 Monoamine oxidase inhibitors
 Serotonin reuptake inhibitors

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Citation

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TY - ELEC T1 - SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE (SIADH) ID - 623415 Y1 - 2017 PB - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623415/all/SYNDROME_OF_INAPPROPRIATE_ANTIDIURETIC_HORMONE__SIADH_ ER -