MIXED CONNECTIVE TISSUE DISEASE (MCTD) is a topic covered in the Harrison's Manual of Medicine.

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Syndrome characterized by a combination of clinical features similar to those of SLE, SSc, polymyositis, and RA; unusually high titers of circulating antibodies to a nuclear ribonucleoprotein (RNP) are found. It is controversial whether MCTD is a truly distinct entity or a subset of SLE or SSc.

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