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RHEUMATOID ARTHRITIS (RA)

RHEUMATOID ARTHRITIS (RA) is a topic covered in the Harrison's Manual of Medicine.

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DEFINITION AND PATHOGENESIS

A chronic multisystem disease of unknown etiology characterized by persistent inflammatory synovitis, usually involving peripheral joints symmetrically. Although cartilaginous destruction, bony erosions, and joint deformity are hallmarks, the course of RA can be quite variable. An association with HLA-DR4 has been noted; both genetic and environmental factors may play a role in initiating disease. The propagation of RA is an immunologically mediated event in which joint injury occurs from synovial hyperplasia; lymphocytic infiltration of synovium; and local production of cytokines and chemokines by activated lymphocytes, macrophages, and fibroblasts.

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Citation

Loscalzo, Joseph, et al., editors. "RHEUMATOID ARTHRITIS (RA)." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623391/all/RHEUMATOID_ARTHRITIS__RA_.
RHEUMATOID ARTHRITIS (RA). In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623391/all/RHEUMATOID_ARTHRITIS__RA_. Accessed August 19, 2019.
RHEUMATOID ARTHRITIS (RA). (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623391/all/RHEUMATOID_ARTHRITIS__RA_
RHEUMATOID ARTHRITIS (RA) [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 August 19]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623391/all/RHEUMATOID_ARTHRITIS__RA_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - RHEUMATOID ARTHRITIS (RA) ID - 623391 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623391/all/RHEUMATOID_ARTHRITIS__RA_ PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -