CONNECTIVE TISSUE DISEASE

CONNECTIVE TISSUE DISEASE is a topic covered in the Harrison's Manual of Medicine.

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DEFINITION

Heterogeneous disorders that share certain common features, including inflammation of skin, joints, and other structures rich in connective tissue; as well as altered patterns of immunoregulation, including production of autoantibodies and abnormalities of cell-mediated immunity. While distinct clinical entities can be defined, manifestations may vary considerably from one pt to the next, and overlap of clinical features between and among specific diseases can occur.

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