To view the entire topic, please sign in or purchase a subscription.
Harrison’s Manual of Medicine 19th edition provides 600+ internal medicine topics in a rapid-access format. Download Harrison’s App to iPhone, iPad, and Android smartphone and tablet. Explore these free sample topics:
-- The first section of this topic is shown below --
DEFINITION
A systemic disorder defined by a clonal expansion of mast cells that in most instances is indolent and nonmalignant. Generally involves bone marrow, skin, gastrointestinal (GI) mucosa, liver, and spleen. Classified as cutaneous mastocytosis with variants and four systemic forms: indolent, associated with concomitant hematologic disorder, aggressive, and mast cell leukemia. Mast cell sarcoma and extracutaneous mastocytomas are rare solid mast cell tumors.
-- To view the remaining sections of this topic, please sign in or purchase a subscription --