Harrison's Manual of Medicine
TOXIC AND DRUG-INDUCED HEPATITIS
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DOSE-DEPENDENT (DIRECT HEPATOTOXINS)
Onset is within 48 h, predictable, necrosis around terminal hepatic venule—e.g., carbon tetrachloride, benzene derivatives, mushroom poisoning, acetaminophen, or microvesicular steatosis (e.g., tetracyclines, valproic acid).
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DOSE-DEPENDENT (DIRECT HEPATOTOXINS)
Onset is within 48 h, predictable, necrosis around terminal hepatic venule—e.g., carbon tetrachloride, benzene derivatives, mushroom poisoning, acetaminophen, or microvesicular steatosis (e.g., tetracyclines, valproic acid).
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