ACUTE CHOLECYSTITIS is a topic covered in the Harrison's Manual of Medicine.

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Acute inflammation of the gallbladder is usually caused by cystic duct obstruction by an impacted stone. Inflammatory response is evoked by (1) mechanical inflammation from increased intraluminal pressure; (2) chemical inflammation from release of lysolecithin; (3) bacterial inflammation, which plays a role in 50–85% of pts with acute cholecystitis.

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