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    PEPTIC ULCER DISEASE

    PEPTIC ULCER DISEASE is a topic covered in the Harrison's Manual of Medicine.

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    Peptic ulcer disease (PUD) occurs most commonly in duodenal bulb (duodenal ulcer, DU) and stomach (gastric ulcer, GU). It may also occur in esophagus, pyloric channel, duodenal loop, jejunum, and Meckel’s diverticulum. PUD results when “aggressive” factors (gastric acid, pepsin) overwhelm “defensive” factors involved in mucosal resistance (gastric mucus, bicarbonate, microcirculation, prostaglandins, mucosal “barrier”) and from effects of Helicobacter pylori.

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    Citation

    Loscalzo, Joseph, et al., editors. "PEPTIC ULCER DISEASE." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623364/all/PEPTIC_ULCER_DISEASE.
    PEPTIC ULCER DISEASE. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623364/all/PEPTIC_ULCER_DISEASE. Accessed April 18, 2019.
    PEPTIC ULCER DISEASE. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623364/all/PEPTIC_ULCER_DISEASE
    PEPTIC ULCER DISEASE [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 18]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623364/all/PEPTIC_ULCER_DISEASE.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - PEPTIC ULCER DISEASE ID - 623364 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623364/all/PEPTIC_ULCER_DISEASE PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -