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RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS is a topic covered in the Harrison's Manual of Medicine.

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Defined as a subacute reduction in GFR of >50%, with evidence of a proliferative GN; causes overlap with those of acute GN (Table 142-2). Broadly classified into three major subtypes on the basis of renal biopsy findings and pathophysiology: (1) immune complex–associated, e.g., in systemic lupus erythematosus (SLE); (2) “pauci-immune,” associated with antineutrophil cytoplasmic antibodies (ANCA); and (3) associated with anti–glomerular basement (anti-GBM) antibodies, e.g., in Goodpasture’s syndrome. All three forms will typically have a proliferative, crescentic GN by light microscopy but differ in the results of the immunofluorescence and electron microscopy components of the renal biopsy.

  1. Infectious diseases
    1. Poststreptococcal glomerulonephritisa
    2. Infective endocarditis
    3. Occult visceral sepsis
    4. Hepatitis B infection (with vasculitis and/or cryoglobulinemia)
    5. HIV infection
    6. Hepatitis C infection (with cryoglobulinemia, membranoproliferative glomerulonephritis)
  2. Multisystem diseases
    1. Systemic lupus erythematosus
    2. Henoch-Schönlein purpura
    3. Systemic necrotizing vasculitis (including granulomatosis with polyangiitis [Wegener’s])
    4. Goodpasture’s syndrome
    5. Essential mixed (IgG/IgM) cryoglobulinemia
    6. Malignancy
    7. Relapsing polychondritis
    8. Rheumatoid arthritis (with vasculitis)
  3. Drugs
    1. Penicillamine
    2. Hydralazine
    3. Allopurinol (with vasculitis)
    4. Rifampin
    5. Cocaine adulterated with levamisole (ANCA-associated)
  4. Idiopathic or primary glomerular disease
    1. Idiopathic crescentic glomerulonephritis
      1. Type I—with linear deposits of Ig (anti-GBM antibody–mediated)
      2. Type II—with granular deposits of Ig (immune complex–mediated)
      3. Type III—with few or no immune deposits of Ig (“pauci-immune”)
      4. Antineutrophil cytoplasmic antibody–induced, forme fruste of vasculitis
      5. Immunotactoid glomerulonephritis
      6. Fibrillary glomerulonephritis
    2. Superimposed on another primary glomerular disease
      1. Mesangiocapillary (membranoproliferative) glomerulonephritis (especially type II)
      2. Membranous glomerulonephritis
      3. Berger’s disease (IgA nephropathy)
aMost common cause.
Abbreviation: GBM, glomerular basement membrane.
Source: RJ Glassock, BM Brenner: HPIM-13.

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Loscalzo, Joseph, et al., editors. "RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623345/all/RAPIDLY_PROGRESSIVE_GLOMERULONEPHRITIS.
RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623345/all/RAPIDLY_PROGRESSIVE_GLOMERULONEPHRITIS. Accessed April 18, 2019.
RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623345/all/RAPIDLY_PROGRESSIVE_GLOMERULONEPHRITIS
RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 18]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623345/all/RAPIDLY_PROGRESSIVE_GLOMERULONEPHRITIS.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS ID - 623345 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623345/all/RAPIDLY_PROGRESSIVE_GLOMERULONEPHRITIS PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -