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ACUTE GLOMERULONEPHRITIS (GN) is a topic covered in the Harrison's Manual of Medicine.

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Often called the “nephritic syndrome.” Characterized by development, over days, of azotemia, hypertension, edema, hematuria, proteinuria, and sometimes oliguria. Salt and water retention are due to reduced glomerular filtration rate (GFR) and may result in circulatory congestion. Red blood cell (RBC) casts on urinalysis confirm diagnosis. Proteinuria is usually <3 g/d. Most forms of acute GN are mediated by humoral immune mechanisms. Clinical course depends on underlying lesion (Table 142-1).

  1. Infectious diseases
    1. Poststreptococcal glomerulonephritisa
    2. Nonstreptococcal postinfectious glomerulonephritis
      1. Bacterial: infective endocarditis, “shunt nephritis,” sepsis, pneumococcal pneumonia, typhoid fever, secondary syphilis, meningococcemia
      2. Viral: hepatitis B, infectious mononucleosis, mumps, measles, varicella, vaccinia, echovirus, and coxsackievirus
      3. Parasitic: malaria, toxoplasmosis
      4. IgA dominant postinfectious glomerulonephritis—usually poststaphylococcal
  2. Multisystem diseases: SLE, vasculitis, Henoch-Schönlein purpura, Goodpasture’s syndrome
  3. Primary glomerular diseases: mesangiocapillary glomerulonephritis, Berger’s disease (IgA nephropathy), “pure” mesangial proliferative glomerulonephritis
  4. Miscellaneous: Guillain-Barré syndrome, irradiation of Wilms’ tumor, self-administered diphtheria-pertussis-tetanus vaccine, serum sickness
aMost common cause.
Source: RJ Glassock, BM Brenner: HPIM-13.

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Loscalzo, Joseph, et al., editors. "ACUTE GLOMERULONEPHRITIS (GN)." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623344/all/ACUTE_GLOMERULONEPHRITIS__GN_.
ACUTE GLOMERULONEPHRITIS (GN). In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623344/all/ACUTE_GLOMERULONEPHRITIS__GN_. Accessed April 23, 2019.
ACUTE GLOMERULONEPHRITIS (GN). (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623344/all/ACUTE_GLOMERULONEPHRITIS__GN_
ACUTE GLOMERULONEPHRITIS (GN) [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623344/all/ACUTE_GLOMERULONEPHRITIS__GN_.
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TY - ELEC T1 - ACUTE GLOMERULONEPHRITIS (GN) ID - 623344 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623344/all/ACUTE_GLOMERULONEPHRITIS__GN_ PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -