ACUTE GLOMERULONEPHRITIS (GN)

ACUTE GLOMERULONEPHRITIS (GN) is a topic covered in the Harrison's Manual of Medicine.

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Often called the “nephritic syndrome.” Characterized by development, over days, of azotemia, hypertension, edema, hematuria, proteinuria, and sometimes oliguria. Salt and water retention are due to reduced glomerular filtration rate (GFR) and may result in circulatory congestion. Red blood cell (RBC) casts on urinalysis confirm diagnosis. Proteinuria is usually <3 g/d. Most forms of acute GN are mediated by humoral immune mechanisms. Clinical course depends on underlying lesion (Table 142-1).

TABLE 142-1: CAUSES OF ACUTE GLOMERULONEPHRITIS
  1. Infectious diseases
    1. Poststreptococcal glomerulonephritisa
    2. Nonstreptococcal postinfectious glomerulonephritis
      1. Bacterial: infective endocarditis, “shunt nephritis,” sepsis, pneumococcal pneumonia, typhoid fever, secondary syphilis, meningococcemia
      2. Viral: hepatitis B, infectious mononucleosis, mumps, measles, varicella, vaccinia, echovirus, and coxsackievirus
      3. Parasitic: malaria, toxoplasmosis
      4. IgA dominant postinfectious glomerulonephritis—usually poststaphylococcal
  2. Multisystem diseases: SLE, vasculitis, Henoch-Schönlein purpura, Goodpasture’s syndrome
  3. Primary glomerular diseases: mesangiocapillary glomerulonephritis, Berger’s disease (IgA nephropathy), “pure” mesangial proliferative glomerulonephritis
  4. Miscellaneous: Guillain-Barré syndrome, irradiation of Wilms’ tumor, self-administered diphtheria-pertussis-tetanus vaccine, serum sickness
aMost common cause.
Source: RJ Glassock, BM Brenner: HPIM-13.

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TY - ELEC T1 - ACUTE GLOMERULONEPHRITIS (GN) ID - 623344 Y1 - 2017 PB - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623344/all/ACUTE_GLOMERULONEPHRITIS__GN_ ER -