LYMPHEDEMA
Chronic, painless edema, usually of the lower extremities; may be primary (inherited) or secondary to lymphatic damage or obstruction (e.g., recurrent lymphangitis, tumor, after surgical excision or irradiation of regional lymph nodes, filariasis).
PHYSICAL EXAMINATION
Marked pitting edema in early stages; limb becomes indurated with nonpitting edema chronically. Differentiate from chronic venous insufficiency, which displays hyperpigmentation, stasis dermatitis, and superficial venous varicosities.
LABORATORY
Abdominal and pelvic ultrasound or CT or MRI to identify obstructing lesions. Lymphangiography or lymphoscintigraphy (rarely done) can confirm diagnosis. If unilateral edema, differentiate from DVT by noninvasive venous studies (earlier).
Treatment: Lymphedema
Treatment: Lymphedema
(1) Meticulous foot hygiene to prevent infection, (2) leg elevation, (3) compression stockings, and/or pneumatic compression boots. Diuretics should be avoided to prevent intravascular volume depletion.
Outline
LYMPHEDEMAis the Harrison's Manual of Medicine Word of the day!
Citation
Kasper, Dennis L., et al., editors. "LYMPHEDEMA." Harrison's Manual of Medicine, 20th ed., McGraw Hill Inc., 2020. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623331/1/LYMPHEDEMA.
LYMPHEDEMA. In: Kasper DLD, Fauci ASA, Hauser SLS, et al, eds. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623331/1/LYMPHEDEMA. Accessed December 8, 2025.
LYMPHEDEMA. (2020). In Kasper, D. L., Fauci, A. S., Hauser, S. L., Longo, D. L., Jameson, J. L., & Loscalzo, J. (Eds.), Harrison's Manual of Medicine (20th ed.). McGraw Hill Inc.. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623331/1/LYMPHEDEMA
LYMPHEDEMA [Internet]. In: Kasper DLD, Fauci ASA, Hauser SLS, Longo DLD, Jameson JLJ, Loscalzo JJ, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. [cited 2025 December 08]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623331/1/LYMPHEDEMA.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - LYMPHEDEMA
ID - 623331
ED - Jameson,J Larry,
ED - Loscalzo,Joseph,
ED - Kasper,Dennis L,
ED - Fauci,Anthony S,
ED - Hauser,Stephen L,
ED - Longo,Dan L,
BT - Harrison's Manual of Medicine
UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623331/1/LYMPHEDEMA
PB - McGraw Hill Inc.
ET - 20
DB - Harrison's Manual of Medicine
DP - Unbound Medicine
ER -

Harrison's Manual of Medicine

