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MALARIA is a topic covered in the Harrison's Manual of Medicine.

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Microbiology and Epidemiology

Six major species of Plasmodium cause nearly all cases of human disease: P. falciparum, P. vivax, two morphologically identical sympatric species of P. ovale, P. malariae, and P. knowlesi.

  • P. falciparum, the cause of most cases of severe disease and most deaths, predominates in Africa, New Guinea, and Hispaniola.
  • P. vivax is more common in Central America.
  • P. falciparum and P. vivax are equally prevalent in South America, the Indian subcontinent, eastern Asia, and Oceania.
  • P. ovale makes up <1% of isolates outside Africa.
  • P. malariae is found in most areas (especially throughout sub-Saharan Africa) but is less common.
  • P. knowlesi (the monkey malaria parasite) can reliably be identified only by molecular techniques and is present in Borneo and Southeast Asia.
  • Malaria is the most important parasitic disease in humans, causing ~2000 deaths each day.

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Loscalzo, Joseph, et al., editors. "MALARIA." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623290/all/MALARIA.
MALARIA. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623290/all/MALARIA. Accessed April 23, 2019.
MALARIA. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623290/all/MALARIA
MALARIA [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623290/all/MALARIA.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - MALARIA ID - 623290 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623290/all/MALARIA PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -