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HISTOPLASMOSIS

HISTOPLASMOSIS is a topic covered in the Harrison's Manual of Medicine.

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Microbiology and Epidemiology

Histoplasma capsulatum, a dimorphic fungus, causes histoplasmosis.

  • Mycelia are infectious and have microconidial and macroconidial forms. Microconidia are inhaled, reach the alveoli, and are transformed into yeasts with occasional narrow budding. A granulomatous reaction results; in pts with impaired cellular immunity, infection may disseminate.
  • Histoplasmosis is the most prevalent endemic mycosis in North America and is also found in Central and South America, Africa, and Asia. In the United States, histoplasmosis is endemic in the Ohio and Mississippi river valleys.
  • The fungus is found in soil, particularly that enriched by droppings of birds and bats.

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Citation

Loscalzo, Joseph, et al., editors. "HISTOPLASMOSIS." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623287/all/HISTOPLASMOSIS.
HISTOPLASMOSIS. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623287/all/HISTOPLASMOSIS. Accessed April 18, 2019.
HISTOPLASMOSIS. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623287/all/HISTOPLASMOSIS
HISTOPLASMOSIS [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 18]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623287/all/HISTOPLASMOSIS.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - HISTOPLASMOSIS ID - 623287 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623287/all/HISTOPLASMOSIS PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -