Cryptococcus is a yeast-like fungus. C. neoformans and C. gattii are pathogenic for humans and can cause cryptococcosis; most clinical laboratories do not routinely distinguish between these species.

  • Worldwide, there are ∼1 million cases of cryptococcosis, with >600,000 deaths annually. Most cases are in pts with AIDS.
  • Cryptococcosis due to C. neoformans is rare in the absence of impaired immunity; in contrast, C. gattiirelated disease often occurs in immunocompetent pts.
  • C. neoformans is found in soil contaminated with pigeon droppings, whereas C. gattii is associated with eucalyptus trees. Most cases are acquired via inhalation, which results in pulmonary infection.

There's more to see -- the rest of this topic is available only to subscribers.