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CANDIDIASIS is a topic covered in the Harrison's Manual of Medicine.

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Microbiology and Epidemiology

Candida is a small, thin-walled, ovoid yeast that reproduces by budding and occurs in three forms in tissue: blastospores, pseudohyphae, and hyphae.

  • Candida is ubiquitous in nature and inhabits the GI tract, the female genital tract, and the skin. Dissemination probably results from fungal entry into the bloodstream from mucosal surfaces after the organisms have multiplied to large numbers as a result of bacterial suppression by antibacterial drugs.
  • C. albicans is common, but non-albicans species (e.g., C. glabrata, C. krusei, C. parapsilosis, C. tropicalis) now cause ~50% of all cases of candidemia and disseminated candidiasis.
    • Candida spp. represent the fourth most common blood-culture isolate from hospitalized pts in the United States.
    • Pts with a compromised immune system, pts with indwelling catheters, pts with severe burns, and neonates of low birth weight are at risk for hematogenous dissemination.

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Loscalzo, Joseph, et al., editors. "CANDIDIASIS." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623283/all/CANDIDIASIS.
CANDIDIASIS. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623283/all/CANDIDIASIS. Accessed April 23, 2019.
CANDIDIASIS. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623283/all/CANDIDIASIS
CANDIDIASIS [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623283/all/CANDIDIASIS.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - CANDIDIASIS ID - 623283 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623283/all/CANDIDIASIS PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -