Scedosporium apiospermum and Lomentospora prolificans (formerly S. prolificans) are molds that are angioinvasive, causing pneumonia and widespread dissemination with abscesses (including brain abscess) in immunocompromised hosts. Most disseminated infections are fatal. These organisms are resistant to AmB, echinocandins, and some azoles. Voriconazole is the agent of choice for S. apiospermum infection, which has a mortality rate of ∼50%; invasive disease caused by L. prolificans, which is resistant in vitro to every available antifungal agent, has a mortality rate of 85–100%.