FUSARIOSIS

FUSARIOSIS is a topic covered in the Harrison's Manual of Medicine.

To view the entire topic, please or .

Harrison’s Manual of Medicine 20th edition provides 600+ internal medicine topics in a rapid-access format. Download Harrison’s App to iPhone, iPad, and Android smartphone and tablet. Explore these free sample topics:

-- The first section of this topic is shown below --

Fusarium species are found worldwide in soil and on plants; inhalation, ingestion, and direct inoculation of spores can cause disease, particularly disseminated disease in immunocompromised pts. Fusariosis is angioinvasive and has clinical manifestations similar to those of aspergillosis. One difference is that painful nodular or necrotic skin lesions are extremely common with disseminated fusariosis. Blood cultures are positive in 50% of cases; the organism is difficult to differentiate from Aspergillus in tissue. Fusarium species are often resistant to antifungal agents; liposomal AmB (≥5 mg/kg qd), voriconazole (200–400 mg bid), or posaconazole (300 mg/d) is recommended. Even with treatment, mortality rates are ∼50%.

-- To view the remaining sections of this topic, please or --

Fusarium species are found worldwide in soil and on plants; inhalation, ingestion, and direct inoculation of spores can cause disease, particularly disseminated disease in immunocompromised pts. Fusariosis is angioinvasive and has clinical manifestations similar to those of aspergillosis. One difference is that painful nodular or necrotic skin lesions are extremely common with disseminated fusariosis. Blood cultures are positive in 50% of cases; the organism is difficult to differentiate from Aspergillus in tissue. Fusarium species are often resistant to antifungal agents; liposomal AmB (≥5 mg/kg qd), voriconazole (200–400 mg bid), or posaconazole (300 mg/d) is recommended. Even with treatment, mortality rates are ∼50%.

There's more to see -- the rest of this topic is available only to subscribers.