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HUMAN HERPESVIRUS (HHV) TYPES 6, 7, AND 8 is a topic covered in the Harrison's Manual of Medicine.

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  • HHV-6 causes exanthem subitum (roseola infantum, a common childhood febrile illness with rash) and 10–20% of febrile seizures without rash in infancy.
    • In older age groups, HHV-6 has been associated with mononucleosis syndromes and (in immunocompromised hosts) encephalitis, pneumonitis, syncytial giant-cell hepatitis, and disseminated disease.
    • More than 80% of adults are seropositive for HHV-6.
  • HHV-7 is frequently acquired during childhood, and infections typically manifest as fever and seizures. The virus is commonly present in saliva.
  • HHV-8 infection in healthy children can present as fever and rash; in immunocompromised pts, primary infection may present as fever, splenomegaly, pancytopenia, and rapid-onset Kaposi’s sarcoma.
    • HHV-8 is associated with Kaposi’s sarcoma, body cavity–based lymphoma in AIDS pts, and multicentric Castleman’s disease.
    • Unlike other herpesvirus infections, HHV-8 infection is much more common in some geographic areas (e.g., central and southern Africa) than in others (North America, Asia, northern Europe).
    • The virus appears to be sexually spread and may also be transmitted in saliva, by organ transplantation, and through IV drug use.

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Loscalzo, Joseph, et al., editors. "HUMAN HERPESVIRUS (HHV) TYPES 6, 7, and 8." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623262/all/HUMAN_HERPESVIRUS__HHV__TYPES_6__7__AND_8.
HUMAN HERPESVIRUS (HHV) TYPES 6, 7, AND 8. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623262/all/HUMAN_HERPESVIRUS__HHV__TYPES_6__7__AND_8. Accessed April 21, 2019.
HUMAN HERPESVIRUS (HHV) TYPES 6, 7, AND 8. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623262/all/HUMAN_HERPESVIRUS__HHV__TYPES_6__7__AND_8
HUMAN HERPESVIRUS (HHV) TYPES 6, 7, and 8 [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 21]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623262/all/HUMAN_HERPESVIRUS__HHV__TYPES_6__7__AND_8.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - HUMAN HERPESVIRUS (HHV) TYPES 6, 7, AND 8 ID - 623262 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623262/all/HUMAN_HERPESVIRUS__HHV__TYPES_6__7__AND_8 PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -