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    HERPES SIMPLEX VIRUSES

    HERPES SIMPLEX VIRUSES is a topic covered in the Harrison's Manual of Medicine.

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    MICROBIOLOGY AND PATHOGENESIS

    The herpes simplex viruses HSV-1 and HSV-2 are linear, double-stranded DNA viruses that share ~50% sequence homology. Exposure to HSV at mucosal surfaces or abraded skin sites permits viral entry and replication in cells of the epidermis and dermis prior to infection of neuronal cells and development of a latent infection in ganglia.

    • Reactivation occurs when normal viral gene expression resumes, with reappearance of the virus on mucosal surfaces.
    • Both antibody-mediated and cell-mediated immunity (including type-specific immunity) are clinically important.

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    Citation

    Loscalzo, Joseph, et al., editors. "HERPES SIMPLEX VIRUSES." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623260/all/HERPES_SIMPLEX_VIRUSES.
    HERPES SIMPLEX VIRUSES. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623260/all/HERPES_SIMPLEX_VIRUSES. Accessed April 23, 2019.
    HERPES SIMPLEX VIRUSES. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623260/all/HERPES_SIMPLEX_VIRUSES
    HERPES SIMPLEX VIRUSES [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623260/all/HERPES_SIMPLEX_VIRUSES.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - HERPES SIMPLEX VIRUSES ID - 623260 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623260/all/HERPES_SIMPLEX_VIRUSES PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -