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    HERPES SIMPLEX VIRUSES

    HERPES SIMPLEX VIRUSES is a topic covered in the Harrison's Manual of Medicine.

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    MICROBIOLOGY AND PATHOGENESIS

    The herpes simplex viruses HSV-1 and HSV-2 are linear, double-stranded DNA viruses that share ~50% sequence homology. Exposure to HSV at mucosal surfaces or abraded skin sites permits viral entry and replication in cells of the epidermis and dermis prior to infection of neuronal cells and development of a latent infection in ganglia.

    • Reactivation occurs when normal viral gene expression resumes, with reappearance of the virus on mucosal surfaces.
    • Both antibody-mediated and cell-mediated immunity (including type-specific immunity) are clinically important.

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    Citation

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    TY - ELEC T1 - HERPES SIMPLEX VIRUSES ID - 623260 ED - Fauci,Anthony S, ED - Hauser,Stephen L, ED - Jameson,J Larry, ED - Kasper,Dennis L, ED - Longo,Dan L, ED - Loscalzo,Joseph, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623260/all/HERPES_SIMPLEX_VIRUSES PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -