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LYME BORRELIOSIS

LYME BORRELIOSIS is a topic covered in the Harrison's Manual of Medicine.

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Microbiology and Epidemiology

Borrelia burgdorferi, the causative agent of Lyme disease, is a fastidious microaerophilic spirochete. The human infection Lyme borreliosis is caused primarily by three pathogenic genospecies: B. burgdorferi sensu stricto (hereafter referred to as B. burgdorferi), Borrelia garinii, and Borrelia afzelii.

  • B. burgdorferi is the sole cause of Lyme borreliosis in the United States; all three genospecies are found in Europe, and the latter two species occur in Asia.
  • Lyme disease is the most common vector-borne illness in the United States, with ~300,000 cases each year.
    • Ixodes ticks transmit the disease.
    • I. scapularis, which also transmits babesiosis and anaplasmosis, is found in northeastern and midwestern states; I. pacificus is found in western states.
  • The white-footed mouse is the preferred host for larval and nymphal I. scapularis. Adult ticks prefer the white-tailed deer as host.
  • Nymphal ticks transmit the disease to humans during the early summer months after feeding for ≥24 h.

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Citation

Loscalzo, Joseph, et al., editors. "LYME BORRELIOSIS." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623249/all/LYME_BORRELIOSIS.
LYME BORRELIOSIS. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623249/all/LYME_BORRELIOSIS. Accessed August 19, 2019.
LYME BORRELIOSIS. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623249/all/LYME_BORRELIOSIS
LYME BORRELIOSIS [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 August 19]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623249/all/LYME_BORRELIOSIS.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - LYME BORRELIOSIS ID - 623249 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623249/all/LYME_BORRELIOSIS PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -