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LEPROSY

LEPROSY is a topic covered in the Harrison's Manual of Medicine.

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MICROBIOLOGY AND EPIDEMIOLOGY

Leprosy is a nonfatal chronic infectious disease caused by M. leprae, an obligate intracellular bacterial species indistinguishable microscopically from other mycobacteria. The organism is confined to humans, armadillos (in some locales), and sphagnum moss.

  • M. leprae cannot yet be cultured in vitro. The organism has a doubling time in mice of 2 weeks (compared with 20 min for Escherichia coli and 1 day for M. tuberculosis).
  • Leprosy, which is associated with poverty and rural residence, is a disease of the developing world; its global prevalence is difficult to assess and is variously estimated at 0.6–8 million.
    • More than 80% of the world’s cases occur in a few countries: India, China, Myanmar, Indonesia, Nepal, Brazil, Nigeria, and Madagascar.
    • In the United States, ~4000 people have leprosy and 100–200 new cases are reported annually.
  • The route of transmission is uncertain but may be via nasal droplets, contact with infected soil, or insect vectors.

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Citation

Loscalzo, Joseph, et al., editors. "LEPROSY." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623247/all/LEPROSY.
LEPROSY. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623247/all/LEPROSY. Accessed April 23, 2019.
LEPROSY. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623247/all/LEPROSY
LEPROSY [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623247/all/LEPROSY.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - LEPROSY ID - 623247 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623247/all/LEPROSY PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -