Chapter 39: Abdominal Pain
Numerous causes, ranging from acute, life-threatening emergencies to chronic functional disease and disorders of several organ systems, can generate abdominal pain. Evaluation of acute pain requires rapid assessment of likely causes and early initiation of appropriate therapy. A more detailed and time-consuming approach to diagnosis may be followed in less acute situations. Table 39-1 lists the common causes of abdominal pain.
| Pain Originating in the Abdomen | |
| Parietal peritoneal inflammation  Bacterial contamination   Perforated appendix or other perforated viscus   Pelvic inflammatory disease  Chemical irritation   Perforated ulcer   Pancreatitis   Mittelschmerz   Blood Mechanical obstruction of hollow viscera  Obstruction of the small or large intestine  Obstruction of the biliary tree  Obstruction of the ureter | Vascular disturbances  Embolism or thrombosis  Vascular rupture  Pressure or torsional occlusion  Sickle cell anemia Abdominal wall  Distortion or traction of mesentery  Trauma or infection of muscles Distension of visceral surfaces, e.g., by hemorrhage  Hepatic or renal capsules Inflammation  Appendicitis  Typhoid fever  Neutropenic enterocolitis or “typhlitis” | 
| Pain Referred from Extraabdominal Source | |
| Cardiothoracic  Acute myocardial infarction  Myocarditis, endocarditis, pericarditis  Congestive heart failure  Pneumonia (especially lower lobes)  Pulmonary embolus |  Pleurodynia  Pneumothorax  Empyema  Esophageal disease, including spasm, rupture, or inflammation Genitalia  Torsion of the testis | 
| Metabolic Causes | |
| Diabetes Uremia Hyperlipidemia Hyperparathyroidism | Acute adrenal insufficiency Familial Mediterranean fever Porphyria C1-esterase-inhibitor deficiency (angioneurotic edema) | 
| Neurologic/Psychiatric Causes | |
| Herpes zoster Tabes dorsalis Causalgia Radiculitis from infection or arthritis | Spinal cord or nerve root compression Functional disorders Psychiatric disorders | 
| Toxic Causes | |
| Lead poisoning Insect or animal envenomation  Black widow spider bites  Snakebites | |
| Uncertain Mechanisms | |
| Narcotic withdrawal Heat stroke | |
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Citation
Kasper, Dennis L., et al., editors. "Chapter 39: Abdominal Pain." Harrison's Manual of Medicine, 20th ed., McGraw Hill Inc., 2020. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623174/all/Chapter_39:_Abdominal_Pain. 
Chapter 39: Abdominal Pain. In: Kasper DLD, Fauci ASA, Hauser SLS, et al, eds. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623174/all/Chapter_39:_Abdominal_Pain. Accessed October 31, 2025.
Chapter 39: Abdominal Pain. (2020). In Kasper, D. L., Fauci, A. S., Hauser, S. L., Longo, D. L., Jameson, J. L., & Loscalzo, J. (Eds.), Harrison's Manual of Medicine (20th ed.). McGraw Hill Inc.. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623174/all/Chapter_39:_Abdominal_Pain
Chapter 39: Abdominal Pain [Internet]. In: Kasper DLD, Fauci ASA, Hauser SLS, Longo DLD, Jameson JLJ, Loscalzo JJ, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. [cited 2025 October 31]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623174/all/Chapter_39:_Abdominal_Pain.
* Article titles in AMA citation format should be in sentence-case
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