Harrison's Manual of Medicine
Chapter 23: Hypoxic-Ischemic Encephalopathy
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Results from lack of delivery of oxygen to the brain because of extreme hypotension or respiratory failure. Most common causes are myocardial infarction (MI), cardiac arrest, shock, asphyxiation, paralysis of respiration, and carbon monoxide or cyanide poisoning. In some circumstances, hypoxemia may predominate. Carbon monoxide and cyanide poisoning are termed histotoxic hypoxemia because they cause a direct impairment of the respiratory chain.
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