Chapter 211: Adverse Drug Reactions
To view the entire topic, please log in or purchase a subscription.
Harrison’s Manual of Medicine 20th edition provides 600+ internal medicine topics in a rapid-access format. Download Harrison’s App to iPhone, iPad, and Android smartphone and tablet. Explore these free sample topics:
-- The first section of this topic is shown below --
Adverse drug reactions are among the most frequent problems encountered clinically and represent a common cause for hospitalization. They occur most frequently in pts receiving multiple drugs and are caused by:
- Errors in self-administration of prescribed drugs (quite common in the elderly);
- Exaggeration of intended pharmacologic effect (e.g., hypotension in a pt given antihypertensive drugs);
- Concomitant administration of drugs with synergistic effects (e.g., aspirin and warfarin);
- Cytotoxic reactions (e.g., hepatic necrosis due to acetaminophen);
- Immunologic mechanisms (e.g., quinidine-induced thrombocytopenia, hydralazine-induced SLE);
- Genetically determined enzymatic defects (e.g., primaquine-induced hemolytic anemia in G6PD deficiency); or
- Idiosyncratic reactions (e.g., chloramphenicol-induced aplastic anemia).
-- To view the remaining sections of this topic, please log in or purchase a subscription --
Adverse drug reactions are among the most frequent problems encountered clinically and represent a common cause for hospitalization. They occur most frequently in pts receiving multiple drugs and are caused by:
- Errors in self-administration of prescribed drugs (quite common in the elderly);
- Exaggeration of intended pharmacologic effect (e.g., hypotension in a pt given antihypertensive drugs);
- Concomitant administration of drugs with synergistic effects (e.g., aspirin and warfarin);
- Cytotoxic reactions (e.g., hepatic necrosis due to acetaminophen);
- Immunologic mechanisms (e.g., quinidine-induced thrombocytopenia, hydralazine-induced SLE);
- Genetically determined enzymatic defects (e.g., primaquine-induced hemolytic anemia in G6PD deficiency); or
- Idiosyncratic reactions (e.g., chloramphenicol-induced aplastic anemia).
There's more to see -- the rest of this topic is available only to subscribers.