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ALS and Other Motor Neuron Diseases

ALS and Other Motor Neuron Diseases is a topic covered in the Harrison's Manual of Medicine.

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Amyotrophic lateral sclerosis (ALS) is the most common form of progressive motor neuron disease (Table 185-1). ALS is caused by degeneration of motor neurons at all levels of the CNS, including anterior horns of the spinal cord, brainstem motor nuclei, and motor cortex. Familial ALS (FALS) represents 5–10% of the total and is inherited usually as an autosomal dominant disorder.

Upper and lower motor neuronAmyotrophic lateral sclerosis
Predominantly upper motor neuronPrimary lateral sclerosis
Predominantly lower motor neuronMultifocal motor neuropathy with conduction block
 Motor neuropathy with paraproteinemia or cancer
 Motor predominant peripheral neuropathies
Associated with other neurodegene­rative disorders 
Secondary motor neuron disorders (see Table 185-2) 
Herpes zoster 
Coxsackie virus 
West Nile virus 

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Loscalzo, Joseph, et al., editors. "ALS and Other Motor Neuron Diseases." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623109/all/ALS_and_Other_Motor_Neuron_Diseases.
ALS and Other Motor Neuron Diseases. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623109/all/ALS_and_Other_Motor_Neuron_Diseases. Accessed April 18, 2019.
ALS and Other Motor Neuron Diseases. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623109/all/ALS_and_Other_Motor_Neuron_Diseases
ALS and Other Motor Neuron Diseases [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 18]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623109/all/ALS_and_Other_Motor_Neuron_Diseases.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - ALS and Other Motor Neuron Diseases ID - 623109 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623109/all/ALS_and_Other_Motor_Neuron_Diseases PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -