Type your tag names separated by a space and hit enter

Hypercholesterolemia and Hypertriglyceridemia

Hypercholesterolemia and Hypertriglyceridemia is a topic covered in the Harrison's Manual of Medicine.

To view the entire topic, please or purchase a subscription.

Harrison’s Manual of Medicine 19th edition provides 600+ internal medicine topics in a rapid-access format. Download Harrison’s App to iPhone, iPad, and Android smartphone and tablet. Explore these free sample topics:

Harrison’s Manual of Medicine - App + Web

-- The first section of this topic is shown below --

Hyperlipoproteinemia may be characterized by hypercholesterolemia, isolated hypertriglyceridemia, or both. Genetic causes of hyperlipoproteinemia are summarized in Table 178-1. Diabetes mellitus, obesity, ethanol consumption, oral contraceptives, glucocorticoids, renal disease, hepatic disease, and hypothyroidism can cause secondary hyperlipoproteinemias or worsen underlying hyperlipoproteinemic states.

Genetic DisorderProtein (Gene) DefectLipoproteins ElevatedClinical FindingsGenetic TransmissionEstimated Incidence
Lipoprotein lipase deficiencyLPL (LPL)Chylomicrons, VLDLEruptive xanthomas, hepatosplenomegaly, pancreatitisAR~1/1,000,000
Familial apo CII deficiencyApo CII (APOC2)Chylomicrons, VLDLEruptive xanthomas, hepatosplenomegaly, pancreatitisAR<1/1,000,000
Apo A-V deficiencyApo A-V (APOA5)Chylomicrons, VLDLEruptive xanthomas, hepatosplenomegaly, pancreatitisAR<1/1,000,000
GPIHBP1 deficiencyGPIHBP1ChylomicronsEruptive xanthomas, pancreatitisAR<1/1,000,000
Combined Hyperlipidemia
Familial hepatic lipase deficiencyHepatic lipase (LIPC)VLDL remnants, HDLPancreatitis, CHDAR<1/1,000,000
Familial dysbetalipoproteinemiaApoE (APOE)Chylomicron remnants, VLDL remnantsPalmar and tuberoeruptive xanthomas, CHD, PVDAR~1/10,000
Familial hypercholesterolemiaLDL receptor (LDLR)LDLTendon xanthomas, CHDAD~1/250 to 1/500
Familial defective apoB-100ApoB-100 (APOB)LDLTendon xanthomas, CHDAD<~1/1500
Autosomal dominant hypercholesterolemia, type 3PCSK9 (PCSK9)LDLTendon xanthomas, CHDAD<1/1,000,000
Autosomal recessive hypercholesterolemiaARH (LDLRAP)LDLTendon xanthomas, CHDAR<1/1,000,000
SitosterolemiaABCG5 or ABCG8LDLTendon xanthomas, CHDAR<1/1,000,000
Abbreviations: AD, autosomal dominant; apo, apolipoprotein; AR, autosomal recessive; ARH, autosomal recessive hypercholesterolemia; CHD, coronary heart disease; LDL, low-density lipoprotein; LPL, lipoprotein lipase; PVD, peripheral vascular disease; VLDL, very-low density lipoprotein.

Standard lipoprotein analysis assesses total cholesterol, HDL cholesterol, and triglycerides with a calculation of LDL cholesterol levels using the following equation: LDL cholesterol = total cholesterol – HDL cholesterol – (triglycerides/5). The LDL cholesterol concentration can be estimated using this method only if triglycerides are <4.0 mmol/L (<350 mg/dL). Both LDL and HDL cholesterol levels are temporarily decreased for several weeks after myocardial infarction or acute inflammatory states, but can be accurately measured if blood is obtained within 8 h of the event.

-- To view the remaining sections of this topic, please or purchase a subscription --


Loscalzo, Joseph, et al., editors. "Hypercholesterolemia and Hypertriglyceridemia." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623100/all/Hypercholesterolemia_and_Hypertriglyceridemia.
Hypercholesterolemia and Hypertriglyceridemia. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623100/all/Hypercholesterolemia_and_Hypertriglyceridemia. Accessed April 18, 2019.
Hypercholesterolemia and Hypertriglyceridemia. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623100/all/Hypercholesterolemia_and_Hypertriglyceridemia
Hypercholesterolemia and Hypertriglyceridemia [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 18]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623100/all/Hypercholesterolemia_and_Hypertriglyceridemia.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Hypercholesterolemia and Hypertriglyceridemia ID - 623100 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623100/all/Hypercholesterolemia_and_Hypertriglyceridemia PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -