Chapter 170: Amyloidosis

Chapter 170: Amyloidosis is a topic covered in the Harrison's Manual of Medicine.

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DEFINITION

Amyloidosis is a term for a group of protein misfolding disorders characterized by the extracellular deposition of insoluble polymeric protein fibrils in tissues and organs. Clinical manifestations depend on anatomic distribution and intensity of amyloid protein deposition; they range from local deposition with little significance to involvement of virtually any organ system with severe pathophysiologic consequences.

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