Harrison's Manual of Medicine
ANKYLOSING SPONDYLITIS
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DEFINITION
AS is a chronic and progressive inflammatory disease of the axial skeleton with sacroiliitis (usually bilateral) as its hallmark. Peripheral joints and extra-articular structures may also be affected. Most frequently presents in second or third decade more commonly in men; strong association with histocompatibility antigen HLA-B27.
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DEFINITION
AS is a chronic and progressive inflammatory disease of the axial skeleton with sacroiliitis (usually bilateral) as its hallmark. Peripheral joints and extra-articular structures may also be affected. Most frequently presents in second or third decade more commonly in men; strong association with histocompatibility antigen HLA-B27.
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