ANKYLOSING SPONDYLITIS

ANKYLOSING SPONDYLITIS is a topic covered in the Harrison's Manual of Medicine.

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Harrison’s Manual of Medicine

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DEFINITION

AS is a chronic and progressive inflammatory disease of the axial skeleton with sacroiliitis (usually bilateral) as its hallmark. Peripheral joints and extra-articular structures may also be affected. Most frequently presents in second or third decade more commonly in men; strong association with histocompatibility antigen HLA-B27.

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