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Chronic Kidney Disease and Uremia

Chronic Kidney Disease and Uremia is a topic covered in the Harrison's Manual of Medicine.

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The prevalence of chronic kidney disease (CKD), generally defined as a long-standing, irreversible impairment of kidney function, is substantially greater than the number of pts with end-stage renal disease (ESRD), now ≥500,000 in the United States. There is a spectrum of disease related to decrements in renal function; clinical and therapeutic issues differ greatly depending on whether the glomerular filtration rate (GFR) reduction is moderate (stage 3 CKD, 30–59 mL/min per 1.73 m2) (see Table 46-1), severe (stage 4 CKD, 15–29 mL/min per 1.73 m2), or “end-stage renal disease” (stage 5 CKD, <15 mL/min per 1.73 m2). Dialysis is usually required once GFR <10 mL/min per 1.73 m2. Common causes of CKD are outlined in Table 139-1.

Diabetic nephropathy
Hypertensive nephropathya
Renovascular disease (ischemic nephropathy)
Polycystic kidney disease
Reflux nephropathy and other congenital renal diseases
Interstitial nephritis, including analgesic nephropathy
HIV-associated nephropathy
Transplant allograft failure (“chronic rejection”)
aOften diagnosis of exclusion; very few pts undergo renal biopsy; may be occult renal disease with hypertension.

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Loscalzo, Joseph, et al., editors. "Chronic Kidney Disease and Uremia." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623056/all/Chronic_Kidney_Disease_and_Uremia.
Chronic Kidney Disease and Uremia. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623056/all/Chronic_Kidney_Disease_and_Uremia. Accessed April 23, 2019.
Chronic Kidney Disease and Uremia. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623056/all/Chronic_Kidney_Disease_and_Uremia
Chronic Kidney Disease and Uremia [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623056/all/Chronic_Kidney_Disease_and_Uremia.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Chronic Kidney Disease and Uremia ID - 623056 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623056/all/Chronic_Kidney_Disease_and_Uremia PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -